Hotels in Cairo, Illinois

Savings up to 60% Off!

Special Rates Available Call 855-516-1090

Make your Cairo Hotel Search Easy







Quality Inn Cairo I-57

13201 Kessler Road, Cairo IL - 62914

(855) 516-1090

0.36 miles

Rating - Quality Inn Cairo I-57

Guests Feel Welcome With Free Daily Breakfast And Rooms Featuring Free Wi-Fi, Mini-Fridges And Microwaves At The Quality Inn Cairo, Which Is Just Off The Interstate. The Two-Story Quality Inn'S 38 Rooms All Feature Free Wi-Fi. The Budget-Friendly Rooms Are Simply Decorated And Also Supply Microwaves, Mini-Fridges And Flat-Panel Tvs. Guests Wake Up To The Complimentary Hot Breakfast Before Heading Out For A Swim In The Seasonal Outdoor Pool, And There Is An Outdoor Picnic Area If Guests Want To Dine Outside. Check With The Front Desk For Copy And Fax Services, And Grab Snacks From The Vending Machine To Satisfy Cravings. Parking Is Free, And Pets Are Welcome For A Fee. In The Southern Tail Of Illinois Near Where The Ohio And Mississippi Rivers Converge, The Quality Inn Sits Just Off I-57. The Small Downtown Of Cairo Is Three Miles Away, And Guests Are Within Five Miles Of Neighboring Missouri And Kentucky. There Are Plenty Of Places To Get Outdoors, Including Fort Defiance State Park, Wickliffe Mounds State Historic Site And Horseshoe Lake, Each Within 20 Minutes Of The Hotel. Lambert St. Louis International Airport Is 160 Miles Northwest.

Read more
Super 8 by Wyndham Charleston MO

310 S Story St, Charleston MO - 63834

(855) 516-1090

10.68 miles

Rating - Super 8 by Wyndham Charleston MO

Complimentary Breakfast, Free Wi-Fi And A Seasonal Outdoor Pool Are The Amenities Offered At Super 8 By Wyndham Charleston Mo. The Single-Story Hotel Has 60 Exterior-Access Rooms Equipped With Microwaves, Mini-Fridges And Cable Television With Hbo. Handicap-Accessible And Non-Smoking Rooms Are Available. Stoke Up On Free Continental Breakfast Before Checking Your Emails With Free Wi-Fi Access. After An Adventure-Filled Day, Unwind With A Swim In The Outdoor Pool. Parking Is Free. The Hotel Is In Charleston, Off I-57 And Easily Accessible To I-55 And I-24. Towosahgy State Historic Site And Big Oak Tree State Park Are Both Less Than 30 Miles Away. Sikeston Memorial Municipal Airport Is 21 Miles Away.

Read more
Quality Inn Charleston I-57

102 Drake St, Charleston MO - 63834

(855) 516-1090

12.24 miles

Rating - Quality Inn Charleston I-57

Complimentary Breakfast, Free Wi-Fi And A Seasonal Outdoor Pool Are Among The Perks Offered By The Quality Inn Charleston. The Two-Story Quality Inn'S 40 Exterior-Access Rooms And Suites Are Well Equipped With Coffeemakers, Microwaves, Mini-Fridges And Cable Tvs With Hbo. Handicap-Accessible And Non-Smoking Rooms Are Available. Start Your Morning With A Free Weekday Newspaper, Hot Waffles And Fresh Brewed Coffee, And Then Head To The Outdoor Pool For A Relaxing Swim. Free Wi-Fi And Local Calling Keep You Connected On The Road. Guests Can Enjoy Complimentary Coffee In The Lobby, As Well As A Coin-Operated Guest Laundry. Pets Are Welcome For A Fee. Parking Is Free. The Quality Inn Is In Charleston, Home To Many Victorian Homes Listed On The Missouri Historic Register. The Inn Is Off I-57 And Easily Accessible To Popular Attractions Including Southeast Missouri State University And Big Oak Tree State Park, Both Within A 45-Minute Drive. The Inn Is 15 Miles From Sikeston Memorial Municipal Airport.

Read more
Americas Best Value Inn Ullin Mounds

128 Cheekwood Lane, Ullin IL - 62992

(855) 516-1090

16.04 miles

Rating - Americas Best Value Inn Ullin Mounds

Freebies Like Wi-Fi And Breakfast Combine With An Indoor Pool At The Non-Smoking Americas Best Value Inn Ullin/Mounds. The Two-Story Americas Best Value Inn Offers 40 Rooms That All Include Free Wi-Fi, Cable Tv, Mini-Fridges, Coffeemakers, Hairdryers And Ironing Equipment, And Non-Smoking Rooms Can Be Requested. A Complimentary Continental Breakfast Is Served Each Morning. The Hotel Also Offers Amenities Like A Seasonally Heated Indoor Pool Means Swimming'S An Option, No Matter The Weather. There'S Also A Business Center And Guest-Use Laundry On-Site. Pets Are Allowed For A Fee, And Parking Is Free. The Hotel Is Off I-57/Us 51, Not Far From The Convergence Of The Mississippi And Ohio Rivers. Nature Enthusiasts Head 10 Miles To Section Eight Woods Nature Preserve. Birdwatchers Swoop Down On The Chestnut Hills Nature Preserve, 11 Miles Away, And Visit Horseshoe Lake, 22 Miles Away. Cairo Regional Airport Is 19 Miles From The Hotel, And Lambert St. Louis International Airport Is 146 Miles Away. The "Always Friendly," "Helpful" Staff Is A Highlight For Our Guests At Americas Best Value Inn Ullin/Mounds, Where Breakfast Is On The House.

Read more
Motel 6 Sikeston MO

110 S Interstate Dr, Sikeston MO - 63801

(855) 516-1090

20.79 miles

Rating - Motel 6 Sikeston MO

Motel 6 Sikeston Mo Offers Accommodation In Sikeston. This 2-Star Hotel Offers A 24-Hour Front Desk. Each Room Comes With A Tv With With Cable Channels.Each Room Is Equipped With A Private Bathroom.Cape Girardeau Is 46 Km From The Hotel. Barkley Regional Airport Is 70 Km From The Property.

Read more
Best Western Plus Sikeston

120 S Interstate Drive, Sikeston MO - 63801

(855) 516-1090

20.86 miles

Rating - Best Western Plus Sikeston

With A Complimentary Daily Breakfast And Free Wi-Fi, Best Western Plus - Sikeston Offers Plentiful Amenities In A Location Near Major Area Businesses And Attractions. This Two-Story Hotel Has 55 Rooms, Some Of Which Are Non-Smoking. Each Room Includes A Work Desk, Cable Tv, Coffeemaker, Microwave, Mini-Fridge And Sofa Bed. Free Wi-Fi Makes It A Snap To Stay In Touch With The Outside World. Guests Swim In The Indoor Pool And Work Out In The On-Site Fitness Room. The Hotel Serves A Complimentary Daily Breakfast Featuring Fresh Coffee And Cinnamon Rolls. Located Near I-55, The Hotel Is One Mile From The Famous Lambert'S Cafe. Sikeston Factory Outlet Mall Is Less Than One Mile Away. The Jaycee Bootheel Rodeo Is Three Miles From The Hotel. Orgill Inc. Is A 10-Minute Drive. Sikeston Memorial Municipal Airport Is Two-And-A-Half Miles Away, And Cape Girardeau Regional Airport Is 26 Miles From The Hotel.

Read more
Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr, Sikeston MO - 63801

(855) 516-1090

20.92 miles

Rating - Days Inn and Suites by Wyndham Sikeston

Including A Free Daily Breakfast, A Seasonal Outdoor Pool, Wi-Fi And In-Room Microwaves And Refrigerators, The Americas Best Value Inn & Suites Is Conveniently Located To The Interstate And Shopping. This Two-Story Hotel Has 60 Rooms, Some Of Which Are Designated Non-Smoking. Pets Are Welcome For A Fee. Each Room Includes Wi-Fi, A Microwave, A Mini-Fridge, A Coffeemaker, Cable Tv With Premium Channels And An Iron With Ironing Board. The Hotel Serves A Free Daily Continental Breakfast. Guests Can Relax In The Seasonal Outdoor Pool. There Is A Business Center And Laundry Facilities Available For Guests' Convenience. Parking Is Free. Located At The Junction Of I-55 And Highway 62, The Americas Best Value Inn & Suites Is Less Than A Mile From The Sikeston Factory Outlet Stores. Sikeston Recreational Complex Is Three Miles Away, And The Famous Lambert'S Cafe Is One Mile. Drive 50 Minutes To Horseshoe Lake, Just Across The Border Into Illinois. Sikeston Memorial Municipal Airport Is Three Miles From The Hotel, And Cape Girardeau Regional Airport Is 27 Miles Away.

Read more
Travel Inn & Suites

100 Matthews Lane, Sikeston MO - 63801

(855) 516-1090

21.14 miles

Rating - Travel Inn & Suites

A complimentary continental breakfast is served daily from 7 AM to 10 AM.

Read more
Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave, Sikeston MO - 63801

(855) 516-1090

21.32 miles

Rating - Super 8 by Wyndham Sikeston/Miner Area

With Free Wi-Fi And A Complimentary Continental Breakfast, The Super 8 By Wyndham Sikeston Is Located Near Many Area Attractions. This Two-Story Hotel Has 63 Rooms, Some Of Which Are Designated Non-Smoking. Pets Are Welcome. Each Room Includes Free Wi-Fi, Cable Tv With Premium Channels, A Hairdryer, A Reclining Chair And A Desk With Lamp. Guests Can Enjoy A Complimentary Continental Breakfast Each Morning To Help Them Get Going. Parking Is Free And Includes Space For Buses And Trucks. The Super 8 By Wyndham Is Located Off I-55, Two Blocks From The Famous Lambert'S Cafe. The Jaycee Bootheel Rodeo Is Three Miles From The Hotel. Sikeston Factory Outlet Stores Are A Half-Mile Away. It'S A 40-Minute Drive To Ten Mile Pond Conservation Area. Sikeston Memorial Municipal Airport Is Two Miles From The Hotel, While Cape Girardeau Regional Airport Is 26 Miles Away.

Read more
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel

115 Hospitality Dr, Sikeston MO - 63801

(855) 516-1090

24.4 miles

Rating - Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel

The Perks Include A Soothing Indoor Pool And Hot Tub, Easy Access To The Highway, Free Breakfast And Complimentary Wi-Fi At The Non-Smoking Holiday Inn Express And Suites Sikeston. The Three-Story Holiday Inn Express Provides Microwaves, Mini-Fridges, Coffeemakers, Flat-Panel Tvs And Free Wi-Fi In All 73 Rooms. Guests Curb Their Morning Hunger Pangs With Complimentary Continental Breakfast. The Heated Indoor Pool Provides A Handy Place To Unwind, And The Fitness Room Is A Welcome Sight For Exercise Fiends. Parking Is Free. The Holiday Inn Express Is Off Highway 60, Within A Block Of Popular Dining And Shopping Spots. It'S Less Than Two Miles South Of Downtown Sikeston And Three Miles West Of I-55. Guests Kick Up Their Heels At The Sikeston Jaycee Bootheel Rodeo, A 10-Minute Drive North. The Hotel Is 30 Miles South Of Cape Girardeau Regional Airport. The Holiday Inn Express And Suites Sikeston Pleases Priceline Guests With Its Convenient Location Close To Highway 60 And I-55.

Read more
Quality Inn Cairo I-57

13201 Kessler Road, Cairo, IL - 62914

0.36 miles

Rating - Quality Inn Cairo I-57

Guests Feel Welcome With Free Daily Breakfast And Rooms Featuring Free Wi-Fi, Mini-Fridges And Microwaves At The Quality Inn Cairo, Which Is Just Off The Interstate. The Two-Story Quality Inn'S 38 Roo...

Read more
Super 8 by Wyndham Charleston MO

310 S Story St, Charleston, MO - 63834

10.68 miles

Rating - Super 8 by Wyndham Charleston MO

Complimentary Breakfast, Free Wi-Fi And A Seasonal Outdoor Pool Are The Amenities Offered At Super 8 By Wyndham Charleston Mo. The Single-Story Hotel Has 60 Exterior-Access Rooms Equipped With Microwa...

Read more
Quality Inn Charleston I-57

102 Drake St, Charleston, MO - 63834

12.24 miles

Rating - Quality Inn Charleston I-57

Complimentary Breakfast, Free Wi-Fi And A Seasonal Outdoor Pool Are Among The Perks Offered By The Quality Inn Charleston. The Two-Story Quality Inn'S 40 Exterior-Access Rooms And Suites Are Well Equi...

Read more
Americas Best Value Inn Ullin Mounds

128 Cheekwood Lane, Ullin, IL - 62992

16.04 miles

Rating - Americas Best Value Inn Ullin Mounds

Freebies Like Wi-Fi And Breakfast Combine With An Indoor Pool At The Non-Smoking Americas Best Value Inn Ullin/Mounds. The Two-Story Americas Best Value Inn Offers 40 Rooms That All Include Free Wi-Fi...

Read more
Motel 6 Sikeston MO

110 S Interstate Dr, Sikeston, MO - 63801

20.79 miles

Rating - Motel 6 Sikeston MO

Motel 6 Sikeston Mo Offers Accommodation In Sikeston. This 2-Star Hotel Offers A 24-Hour Front Desk. Each Room Comes With A Tv With With Cable Channels.Each Room Is Equipped With A Private Bathroom.Ca...

Read more
Best Western Plus Sikeston

120 S Interstate Drive, Sikeston, MO - 63801

20.86 miles

Rating - Best Western Plus Sikeston

With A Complimentary Daily Breakfast And Free Wi-Fi, Best Western Plus - Sikeston Offers Plentiful Amenities In A Location Near Major Area Businesses And Attractions. This Two-Story Hotel Has 55 Rooms...

Read more
Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr, Sikeston, MO - 63801

20.92 miles

Rating - Days Inn and Suites by Wyndham Sikeston

Including A Free Daily Breakfast, A Seasonal Outdoor Pool, Wi-Fi And In-Room Microwaves And Refrigerators, The Americas Best Value Inn & Suites Is Conveniently Located To The Interstate And Shopping. ...

Read more
Travel Inn & Suites

100 Matthews Lane, Sikeston, MO - 63801

21.14 miles

Rating - Travel Inn & Suites

A complimentary continental breakfast is served daily from 7 AM to 10 AM.

Read more
Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave, Sikeston, MO - 63801

21.32 miles

Rating - Super 8 by Wyndham Sikeston/Miner Area

With Free Wi-Fi And A Complimentary Continental Breakfast, The Super 8 By Wyndham Sikeston Is Located Near Many Area Attractions. This Two-Story Hotel Has 63 Rooms, Some Of Which Are Designated Non-Sm...

Read more
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel

115 Hospitality Dr, Sikeston, MO - 63801

24.4 miles

Rating - Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel

The Perks Include A Soothing Indoor Pool And Hot Tub, Easy Access To The Highway, Free Breakfast And Complimentary Wi-Fi At The Non-Smoking Holiday Inn Express And Suites Sikeston. The Three-Story Hol...

Read more

Map of Cairo Hotels

View all Cairo, Illinois hotels, motels, lodging and attractions on Cairo, Illinois location map.


Weather Forecast for Cairo, Illinois

Traveling to Cairo, Illinois? Here is your 6-day weather forecast in the area. Whether it is a warm weather destinations or cold climate don’t forget to consider weather, while you pack your bags for this trip. Start your day when the sunrises at 12:40 PM and don’t miss the sunset at 10:42 PM. Today’s winds are traveling west-northwest at a speed of 12 MPH. The temperature feels like 47 with a humidity level of 61. Cloud coverage is 15 percent with 13.2 percent visibility. Today’s UV index is 3 make sure to prepare properly. Make sure to plan your travel itinerary to match your travel weather forecast to make the most of your vacation with Reservations.com.


Fahrenheit / Celsius
Wednesday 11/20
Few clouds

Wednesday 11/20 Weather forecast for Cairo, Illinois, Few clouds
51°F
High: 59°F
Low: 37°F
Precipitation: 10%
Today 11/21
Few clouds

Thursday 11/21 Weather forecast for Cairo, Illinois, Few clouds
42°F
High: 49°F
Low: 35°F
Precipitation: 0%
Friday 11/22
Scattered clouds

Friday 11/22 Weather forecast for Cairo, Illinois, Scattered clouds
41°F
High: 51°F
Low: 32°F
Precipitation: 0%
Saturday 11/23
Scattered clouds

Saturday 11/23 Weather forecast for Cairo, Illinois, Scattered clouds
42°F
High: 55°F
Low: 37°F
Precipitation: 0%
Sunday 11/24
Broken clouds

Sunday 11/24 Weather forecast for Cairo, Illinois, Broken clouds
52°F
High: 61°F
Low: 56°F
Precipitation: 0%
Monday 11/25
Overcast clouds

Monday 11/25 Weather forecast for Cairo, Illinois, Overcast clouds
59°F
High: 66°F
Low: 52°F
Precipitation: 35%

FAQs about hotels in Cairo

Find answers to commonly asked questions about Cairo hotels

Fun things to do in Cairo Area

Top tourist attractions and popular landmarks in Cairo.

Cairo Surrounding cities

Best suburbs, counties and towns near Cairo, Illinois.

Loading...